The recent discussion revolves around a pre-print study suggesting the presence of microplastics in human brain tissue. While this topic raises concerns about health implications, several commenters express skepticism about the study's methodology, particularly the extrapolation of tiny sample measurements to larger organ weights. They point out significant variations in microplastic measurements and suggest that current estimates might not accurately reflect actual risks. Despite this uncertainty, there is an underlying worry about the increasing accumulation of microplastics in the environment, primarily from sources like car tire degradation. Some participants noted potential body clearance of these microplastics, highlighting a need for further research to understand internal concentrations and effects better.