The recent failure of a large reproducibility project in the biomedical field has sparked significant discussion around the challenges of validating scientific studies. A key issue raised is the lack of publication opportunities for studies that yield negative results, which could contribute to the perpetuation of false positives in scientific literature. Comments from the community emphasize the importance of assessing the impact of non-reproducible findings and advocate for a systemic overhaul in how research is validated before it enters major journals. The discussion also touches on the need for open communication within the scientific community to establish consensus and the potential benefits of rigorous approaches to scientific inquiry, such as attempting to falsify existing theories. Moreover, a comment about adopting alternative operating systems for better reproducibility also highlights a technical aspect of research processes.