The ongoing formation of microbial ecosystems aboard the International Space Station (ISS) highlights the resilience of bacteria in extraterrestrial environments. Despite efforts at sterilization, it is almost impossible to eliminate all bacterial presence, raising questions about microbial management in long-term human space missions. The human body itself is a significant source of these microorganisms, and attempts to completely eradicate them may lead to health challenges for astronauts. The comments reference the historical presence of mold on Soviet space stations, suggesting that such microbial diversity is not a new phenomenon in space exploration.