Recent research highlights fluoxetine, an antidepressant, as a promising treatment approach for sepsis due to its ability to enhance IL-10 dependent metabolic defenses. By improving survival rates in disease models, fluoxetine showcases antimicrobial properties and modulates inflammatory responses, potentially revolutionizing strategies for managing sepsis. This opens up discussions around how antidepressants might positively influence immune responses and metabolic functions during severe infections.