The discussion revolves around the use of CMake for setting up a 2D game project in Swift, highlighting the possibilities for cross-platform game development. While CMake facilitates interoperation between Swift and C/C++, there are suggestions from users that the Swift Package Manager (SPM) might be more suitable for purely Swift-based projects. Users express excitement about using Swift for expanding game development beyond iOS and macOS, seeking clarity on the feasibility of targeting other platforms.