The article discusses the challenges faced in simulating the neural behavior of Caenorhabditis elegans (C. elegans), a model organism widely used in neuroscience research. Despite the availability of its complete connectome, simulating this worm's neural network remains an arduous task, illustrating the complexities of biological systems. The comments highlight the excitement around understanding biological neurons, the limitations of current simulation efforts (such as the Open Worm project), and the significant computational resources required for accurate simulations. It's an ongoing pursuit to break down the intricacies of a seemingly simple organism, shedding light on broader computational and biological challenges.