As we age, particularly past the age of 80, there appears to be a notable decline in the risk of developing cancer. This phenomenon has been partially attributed to biological changes, such as increased levels of the protein NUPR1, which limit cell regeneration and promote a state akin to iron deficiency in older cells. Lower metabolic activity, reduced cell replication, and changes in lifestyle factors contribute to this decrease in cancer incidence. However, some discussions suggest this may also be influenced by a selection effect where individuals prone to cancer don't survive past older ages, leading to a skewed perception of risks. Overall, the relationship between aging and cancer risk highlights a complex interplay between biological age, metabolism, and cellular repair mechanisms.